Endogenous agmatine synthesis in mammals was discovered
Agmatine was discovered by Albrecht Kossel in 1910. The term is derived from A- (for amino) + g- (from guanidine) + -ma- (from ptomaine) + -in (German)/-ine (English) suffix inserted -t- apparently for ear-pleasing. [3] A year later, agmatine was found to increase blood flow in rabbits;[4] however, the physiological relevance of these findings was questioned given the high concentrations required (high ?M range). [5] In the 20s, researchers at the Oskar Minkowski Diabetes Clinic showed that agmatine exerted a mild hypoglycemic effect. [6] In 1994, endogenous agmatine synthesis in mammals was discovered.
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