In 1806, Joseph Louis Proust discovered mannitol. [9] It is on the World Health Organization's list of essential medicines. [10] It was originally made from the ashes of the flowers and was called manna due to its resemblance to the biblical food. [11][12] Mannitol was placed on the World Anti-Doping Agency's list of banned substances due to concerns that it could mask other drugs. In the United States, mannitol is used to lower intracranial pressure and to treat cerebral edema and elevated intraocular pressure. [2] In the European Union, mannitol is designated for the treatment of cystic fibrosis (CF) in adults aged 18 years and over as an add-on therapy to the best standard of care.
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