Gemini19

Name	:	gemini19
Website	:	Visit Website
Blog	:	Visit Blog
Social Links	:

About Gemini19

Fleximers are different series of flexible, or "split,� purine base analogues designed to learn how nucleobase flexibility affects the recognition, binding, and activity of nucleoside (tide) analogues. There is a purine base scaffold in the fleximers. With this purine base scaffold, the imidazole and pyrimidine moieties are combined by a single carbon-carbon bond rather than being "fused,� as is typical for the purines. In previous reports, a number of novel fleximers have been screened, and these fleximers can combine the flex-base motif with the flexible acyclic sugar scaffold of the FDA-approved drug acyclovir (serves as a polymerase inhibitor). Studies have demonstrated that these fleximers can inhibit HCoV-NL63 and MERS-CoV replication in cell culture. However, it is still unknown how these novel analogues disrupt viral replication. In summary, acyclovir fleximers for SARS-CoV-2 are a group of promising drug candidates for the new drug discovery

RNA imaging for SARS-CoV-2

Gemini1928 Aug, 2023Other

The olecular biology and immunology experts have extensive experience in developing in vitro diagnostic assays. Using our advanced RNA imaging for SARS-CoV-2, we can help customers accelerate the process of developing high-quality COVID-19 test kits.

Microfluidic Chip Development Service

Gemini1926 Jul, 2023Science

Microfluidic chips have gradually become powerful tools for biological analysis in the fields of fundamental biology, clinical applications, food safety, and environmental monitoring due to their high sensitivity, high throughput, and low cost. Among them, the timely detection and analysis of biologically active small molecules such as oligonucleotides, oligopeptides, oligosaccharides, vitamins, minerals, and metabolites in physiological processes is very important for guiding therapeutic medication and predicting disease prognosis.

Cancer therapy by exosomes

Gemini1926 Jul, 2023Other

Cancer remains one of the leading causes of death due to its late diagnosis, poor prognosis, and frequent occurrence of drug resistance and metastasis. Cancer therapy by exosomes transfer bioactive molecules between cancer and other cells and modulate the biological functions of recipient cells, thus participating in the progression and metastasis of multiple cancers.

Bispecific Non-IgG Antibody Service

Gemini1926 Jul, 2023Science

Attracted by the distinctive advantages of BsAb and non-IgG antibodies (mainly IgA, IgM, and IgE), scientists at Creative Biolabs are trying their best to develop potential bispecific non-IgG antibodies in recent years. Development of BsAb is an extremely fast-growing field with innovative formats emerging constantly. As a senior biotechnology company with strong comprehensive strength, Creative Biolabs endeavors to develop the most comprehensive and the highest quality BsAb service.

Cell & Organelle Imaging

Gemini1926 Jul, 2023Business

Creative Biolabs offers a comprehensive range of quality recombinant antibodies for cell and organelle imaging. These antibodies cover significant research areas such as cancer research, cell signaling, cell morphology, and organelle detection. Live cell imaging is the study of living cells using time-lapse microscopy. Scientists use it to better understand and validate biological functions through the study of cellular dynamics. Organelles are specialized and well-defined parts of the cell that are usually separately enclosed within their own lipid bilayers. Very often, organelles have to be stained to follow cellular processes and the effects of changing parameters on these processes. Thus, there is a strong need for tools to stain and follow specific organelles in living cells.

Patient Genome Sequencing

Gemini1926 Jul, 2023Health

Next-generation sequencing (NGS) is a technique that can fundamentally change the perception of scientific and diagnostic issues. This technology produces large amounts of sequencing data at a lower price point, leading to a series of breakthroughs and unfolding a new era of bioinformatics and biostatistical data analysis. Creative Biolabs is a leading provider of genomic services. The researchers in our team not only have profound knowledge not only in the field of NGS, but also in clinical research, molecular biology and related specialties. Their background and hands-on experiences enable us to provide comprehensive services for our clients covering DNA and RNA sample preparation, extraction, genotyping, and other NGS and gene expression studies.

Fc-Fusion Protein Development

Gemini1926 Jul, 2023Other

IgG molecules of the IgG1, IgG2, and IgG4 subclasses exhibit exceptionally long half-lives due to FcRn-mediated recycling. Half-lives of up to 4 weeks have been described for therapeutic antibodies. The binding site for FcRn resides in the Fc region, which is formed by the CH2 and CH3 domains. Thus, fusion to an Fc? region endows a therapeutic protein with the half-life extension properties (increased size, FcRn recycling) of immunoglobulins. Fc fusion protein development represents one of the most clinically successful half-life extension strategies to date and has been used in the development of a major portion of the fusion proteins. A wide range of molecules, from small peptides to larger proteins, are suitable for fusion to the Fc region, suitable molecules include hormones, growth factors, blood proteins, and protein or peptide mimetic

General Targets of Ribosome

Gemini1926 Jul, 2023Business

General Targets of Ribosome Decoding Center The decoding center (DC) is the region comprising the A site on the 30S subunit that monitors the correct base pairing between the mRNA codon and the anticodon of the aa-tRNA. This part of the ribosome consists of regions of the 30S head and shoulder, and the top of helix 44 (h44) of 16S rRNA. Antibiotics belonging to several different chemical classes bind in the DC, and some of them are used to treat a broad range of infections.

Polysialylation Based Half-Life Extension

Gemini1916 Jun, 2023Health

The prolonged residence of polysialylated conjugates increases the species' potential to reach its target and provide a therapeutic effect before being cleared from circulation, thereby extending the duration of action. We are an innovative, experienced provider of polysialylation half-life extension drug development solutions. We use our state-of-the-art R&D and manufacturing expertise to help our customers develop stand-out products.

Midbody Antibody

Gemini1916 Jun, 2023Technology

Creative Biolabs provides a range comprehensive of recombinant antibodies using in the research of midbody. The midbody is a transient structure found in mammalian cells and is present near the end of cytokinesis just prior to the complete separation of the dividing cells. Structurally, the midbody contains a series of microtubules which are derived from the mitotic spindle which compacts during the final stages of cell division. It has a typical diameter of 1 micrometre and a length of 3 to 5 micrometres. In addition to microtubules it also contains a broad range of proteins which are involved in cytokinesis, asymmetric cell division, and chromosome segregation.