NAA Associated Pulmonary Alveolar Proteinosis (PAP)

Creativebiolabs26 Dec, 2023Health

Introduction of Pulmonary Alveolar Proteinosis (PAP) PAP includes part of a spectrum of disorders of surfactant homeostasis (clearance and production). Surfactant is synthesized and secreted by alveolar type II epithelial cells, removed by uptake, recycling, and catabolism in these epithelial cells and by uptake and catabolism in alveolar macrophages. Pulmonary surfactant maintains lung function by creating an air-liquid interface on the alveolar surface, reducing surface tension and preventing alveolar collapse. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for the catabolism of surfactant in alveolar macrophages.