NAA Associated Primary Liver Cancer

Creativebiolabs26 Dec, 2023Health

PLC is one of the common malignant tumors. Due to its insidious onset, nonspecific presenting symptoms in its early stage, and quick progression, PLC usually has been in the advanced stage or develops distant metastasis when it is confirmed. The main clinical manifestations of PLC includes pain in the hepatic region, loss of appetite, emaciation, weakness, and fever. PLC comprises a heterogeneous group of malignant tumors with different histologic features and unfavorable prognosis that range from intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) to mixed iCCA and HCC, pediatric neoplasm hepatoblastoma and the fibrolamellar HCC. Among these, iCCA and HCC are the most common PLCs. Risk factors for iCCA development include primary sclerosing cholangitis, biliary duct cysts, hepatolithiasis and parasitic biliary infestation with flukes. The main risk factors associated with HCC include viral hepatitis (HBV, and/or HCV), alcohol abuse and non-alcoholic fatty liver d