Bocsci2018

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Dasatinib carbaldehyde

Bocsci201821 Oct, 2021News

Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER. Dasatinib carbaldehyde, the Dasatinib (ABL inhibitor) moiety, binds to IAP ligand via a linker to form SNIPER.

Compound 3i

Bocsci201821 Oct, 2021News

Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development. Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development. Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development. Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development. Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development. Compound 3i is a VHL-based PROTAC targeting the TANK-binding kinase 1 (TBK1), which has been implicated in innate immune response, tumorigenesis, and development.

CMP 98

Bocsci201821 Oct, 2021News

N1,N20-bis((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide N1,N20-bis((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide N1,N20-bis((S)-1-((2S,4S)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide

CM 11

Bocsci201821 Oct, 2021News

CM 11 is a homo-PROTAC for self-degradation of pVHL30 with a 1000-fold increased cellular activity compared to the VHL ligand VH 032. CM 11 is a homo-PROTAC for self-degradation of pVHL30 with a 1000-fold increased cellular activity compared to the VHL ligand VH 032. CM 11 is a homo-PROTAC for self-degradation of pVHL30 with a 1000-fold increased cellular activity compared to the VHL ligand VH 032. CM 11 is a homo-PROTAC for self-degradation of pVHL30 with a 1000-fold increased cellular activity compared to the VHL ligand VH 032. CM 11 is a homo-PROTAC for self-degradation of pVHL30 with a 1000-fold increased cellular activity compared to the VHL ligand VH 032.

Imidazopyridines Building Blocks

Bocsci201821 Oct, 2021News

6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride 6-Methylimidazo[1,2-a]pyridine-2-methanamine Dihydrochloride

Imidazoles Building Blocks

Bocsci201821 Oct, 2021News

alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol alpha-(Trifluoromethyl)-1-methyl-1H-imidazole-2-methanol

Heterocyclic product

Bocsci201821 Oct, 2021News

The search for biologically active compounds is the driving force in pharmaceutical synthesis. Since the majority of new molecules entering clinical studies contains at least one heterocyclic moiety predominantly N-heterocyclic ones the modification of these ring systems plays an important role during drug development. The search for biologically active compounds is the driving force in pharmaceutical synthesis. Since the majority of new molecules entering clinical studies contains at least one heterocyclic moiety predominantly N-heterocyclic ones the modification of these ring systems plays an important role during drug development.

Halides Building Blocks

Bocsci201821 Oct, 2021News

2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene 2-Iodo-4-nitro-1-(trifluoromethoxy)benzene

Benzopyrans Building Blocks product

Bocsci201828 Sep, 2021Other

7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one 7-Bromo-4-hydroxy-2H-chromen-2-one

Benzotriazoles Building Blocks product

Bocsci201828 Sep, 2021Other

6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole 6-(Boc-aminomethyl)-1,2,3-benzotriazole