Sphingolipids are a class of lipids with eighteen carbon amino-alcohol backbones synthesized from nonsphingolipid precursors. The different modifications of this basic structure leading to a large number of sphingolipids. Although sphingolipids contain various structures and functions, the biosynthesis and degradation pathway for these sphingolipids are the same. Therefore, the sphingolipid metabolism is a mutual network different from a single common biosynthesis pathway and converge into a single common degradation pathway. The simplest forms of sphingolipids are sphingosine, phytosphingosine and dihydrosphingosine. They function as the backbones for other complex groups of sphingolipids. These compounds play important roles in signal transduction and cell recognition. Disorders of sphingolipid metabolism links to various human diseases like Gaucher disease and Fabry disease. Understanding how the sphingolipid metabolism is regulated via contributes to exploring the underlying mechan
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