Pomalidomide-PEG2-Alkyne

Bocsci201831 Aug, 2021Other

Pomalidomide-PEG2-Alkyne is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal alkyne for click chemistry with an azide on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Pomalidomide-PEG2-Alkyne is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal alkyne for click chemistry with an azide on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.