New Molecule Found Effective Against COVID-19
ATN-161, a small pentapeptide ?5?1 integrin inhibitor, has several properties that make it potentially attractive as a novel SARS-CoV-2 therapy. It is safe and well tolerated with no dose-limiting toxicity as per phase I cancer clinical trials . K18-hACE c57BL/6 J mice were inoculated with either saline or SARS-CoV-2 via intranasal administration. Post inoculation, one group of infected mice received ATN-161 (1 mg/kg), while the other received saline. The viral copy number, SARS-CoV2 gene expression, SARS-CoV2 antigen detection and histological studies of the lungs were carried out. The results were compared between infected mice with and without ATN-161 therapy.
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