FBDD screening method

Vivian Smith14 Jun, 2023Science

The wide application of FBDD shows that the method is becoming more and more mature, but many papers also show that FBDD is still an evolving subject, such as the application of new reactions and new technologies (microfluidics and automation) in fragment synthesis, and the development of technologies in fragment screening (Such as Cryo-EM, XFELs and SFX) and expanded fragment library innovations (such as MiniFrag, FragLites), etc. These help us analyze the interaction between fragments and proteins, feedback library design information, and tell us how to optimize fragments more effectively.