Familial amyloid cardiomyopathy is caused by the accumulation and deposition of mutant and wild-type transthyretin protein (TTR) in the heart. It usually develops after the age of 60. Hereditary cardiac transthyretin amyloidosis or hereditary amyloid cardiomyopathy are other names for familial amyloid cardiomyopathy. Transthyretin amyloid fibrils invade the myocardial, causing restrictive cardiomyopathy and diastolic dysfunction, which eventually leads to heart failure.
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