The idea of administering drugs and fluids through the medullary (marrow) chamber of a bone dates back to the 1920s, when adults with pernicious anaemia were transfused through their sternum. The medullary cavity in long bones is made up of a network of venous sinusoids. These sinusoids drain into massive medullary venous channels, which lead to nutrition or emissary venous systems. The nutrition foramina allow these arteries to escape the bone and empty directly into the systemic venous circulation.
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