Cell and Animal Models for Antivirals against Hepatitis B Virus
Hepatitis B virus (HBV) is the smallest known DNA virus in humans, with a genome length of approximately 3.2 kb and partially double-stranded DNA. It belongs to the Hepadnaviridae family, has a strict tropism for the liver and species-specificity, and generally infects liver tissues, causing acute and chronic hepatitis. In its natural state, it can only infect humans and a few primate species. These characteristics limit the application of animal models in HBV research.
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