Bjerre Wilcox

About Bjerre Wilcox

KPV is a tripeptide composed of the amino acids lysine, proline and valine in that order. It is one of the simplest naturally occurring peptides yet it has attracted considerable scientific interest because of its potent anti-inflammatory properties. The sequence LYSINE-PROLINE-VALINE (often written as KPV) was first identified as a fragment derived from human β-defensin 1, an antimicrobial peptide that plays roles in innate immunity and inflammation regulation. The unique structure of KPV confers several functional advantages. Lysine provides a positively charged side chain at physiological pH, which facilitates interaction with negatively charged components of cell membranes and extracellular matrix molecules. Proline introduces a rigid kink that can influence the peptide’s