Xanax may be taken orally with or without food. Take it with food if you experience stomach problems. Xanax may be taken every day at fixed intervals or on an as-needed basis. Typically, your pharmacist will limit the number of doses you should have in one day. Your provider will decide the best dose and method of taking Xanax that is right for you based upon different factors like your age, health, the severity of the condition. Xanax orally disintegrating tablets must remain in their actual packaging. Open the package with clean and dry hands before each dose. Xanax orally disintegrating pills will dissolve in your mouth within a couple of seconds and can be swallowed with or without liquid. Do not crush, chew or break an E.R. tablet. Swallow them as a whole.