What is the important rule of scale-up into animal cell culture?

Kosheeka : Primary Cells For Research28 Nov, 2024Other

Scaling up animal cell culture requires maintaining a consistent microenvironment to ensure cells grow and behave uniformly across all scales. Key considerations include optimizing nutrient and gas exchange, minimizing shear stress with gentle bioreactors, and precisely controlling pH and temperature. Standardization and monitoring are crucial to ensure reproducibility and efficiency. These practices pave the way for successful large-scale applications in research and therapy.