Erectile dysfunction has been associated with several risk factors. Sexual activity at an early age is also considered to be one of them. The scientific evidence does not directly link adolescent sexual activity to erectile dysfunction. But emotional distress and prolonged use of performance enhancing drugs have been identified as mediators between early sexual activity and erectile dysfunction. Although several medications are available, they provide only short-term relief. Stem cells, on the other hand, have provided remarkable outcomes in erectile dysfunction.