Lyme disease is widely recognized for its physical symptoms like fatigue, joint pain, and neurological issues. However, one of the lesser-known yet deeply impactful aspects of Lyme disease is the way it can lead to personality changes. When the infection affects the brain and nervous system, individuals may experience shifts in mood, behavior, and cognitive function. Some report increased irritability, depression, anxiety, or sudden emotional outbursts. Others may struggle with confusion, memory lapses, or even personality traits that seem completely out of character.