The SARS-CoV-2 virus enters the cells by binding to Dipeptidyl peptidase-4. The dipeptidyl peptidase-4 (DPP-4) inhibitors have shown benefits in decreasing the mortality and severity associated with SARS?CoV-2 infection. DPP-4 has the potential to block the host CD26 receptor and modulate the DPP4/CD26 activity consequently restricting SARS?CoV-2 from entering the T cells.
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