TCR Binding Prediction

Vivian Smith08 Jul, 2024Health

Recognition of pathogenic peptides contained in major histocompatibility complex (MHC) molecules is an early event in the T cell mediated immune response. Successful recognition of antigenic peptides bound to MHC (pMHCs) requires specific binding of the T Cell Receptor (TCR) to these complexes. Each chain of TCR consists of two immunoglobulin-like domains, the variable domain (V? and V?) and the constant domain (C? and C?). In the vertebrate immune system, tremendous T cell variants, different from each other in the TCR, are encoded by gene segments joined in a process known as v(d)j recombination, which occurs during the T cell maturation in the thymus.