Spravato (esketamine) is an innovative FDA-approved medication for depression that is specifically designed to treat treatment-resistant depression. It can often provide relief when traditional medications have not been effective. By targeting the glutamate system, Spravato nasal spray works differently from conventional therapies and can offer rapid relief for many patients. If you or someone you care about is struggling with treatment-resistant depression or major depressive disorder, visit Wilshire Institute to learn how the Wilshire Institute for Interventional Psychiatry can help.