Spindle cell sarcoma is a very rare malignant tumor which can develop in bone or soft tissue. This tumor can arise in any part of the body but can be mostly seen in limbs. It is the type of connective tissue tumor and generally begins in the layer of connective tissues. Chemotherapy is the most important treatment for this disease. Various chemotherapy drugs are also used to cure this tumor. Spindle cell sarcoma is diagnosed by the presence of a tumor on the surface of the tissue and will be confirmed by carrying out various diagnostic tests such as X-rays, MRI scan, and other imaging devices.