When QuickBooks not calculating payroll taxes, it can cause significant payroll issues for businesses. This problem may arise due to incorrect payroll setup, outdated tax tables, or software glitches. Users need to ensure that payroll items are correctly configured and that the software is up-to-date. Additionally, verifying employee and company tax settings is essential. Addressing these issues promptly ensures accurate tax calculations, compliance with regulations, and smooth payroll processing. Seeking QuickBooks support may be necessary for complex issues. For persistent issues, consult QuickBooks support or a certified professional for assistance at 1.855.409.2300.