RNA Synthesis | Compounds for RNA Synthesis | kbDNA

Kbdna, Inc01 Oct, 2021Science

The synthesis of RNA is conventionally more sensitive than DNA. This poses challenges in developing very similar synthesis compounds such as amidites and supports, but with the right chemistry to counter RNA-specific hurdles. Stability and structural confirmation are routine offenders, and both can be countered by utilizing backbone phosphorothioation and reverse synthesis techniques.