Rheumatic fever can occur at any age however occurs most often among ages 5 to 15 years. In the U.S., rheumatic fever hardly develops before age of 3 and after the age of 21 and is much less common than in developing economies, possibly because antibiotics are extensively used to treat streptococcal infections at a prompt stage. Though, the incidence of rheumatic fever sometimes increases and falls in a specific area for unknown reasons. The living conditions, malnourishment and undernutrition, and lower social life and economic status seem to upsurge the risk of rheumatic fever.
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