Neopterin is released by macrophages during inflammatory responses leading to cytokine storms, a hall-mark of SARS-CoV-2 infection. Hence, a case-control design study was conducted to analyze the association of serum neopterin levels with COVID-19. A total of 610 individuals participated of which 374 were hospitalized COVID-19 patients and 256 were healthy donors. Hospitalized COVID-19 patients were all symptomatic and displayed a large spectrum of comorbidities.
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