Using optogenetic stimulation, Zhizhong Pan and colleagues brand dual hostile neural pathways — one that carries pain signals from a parabrachial iota to a executive iota of amygdala (PBN-CeA) and another from a basolateral amygdala to CeA (BLA-CeA) — that confederate disastrous and certain emotion. Activating a PBN-CeA circuit generated anxiety- and depression-like behaviors in
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