Interplay between Multiple Sclerosis and SARS-CoV-2

Sailender02 Nov, 2021Health

Immunological pathways dysregulated in COVID-19 largely overlap with multiple sclerosis (MS) pathogenetic mechanisms. In COVID-19 brains, choroid barrier cells and glia limitans release chemokines toward brain parenchyma and promote complement activation, fueling neuroinflammation and neural damage. A similar mechanism is described in MS, where an activated choroid epithelium in response to peripheral inflammation activates pathogenic B and T lymphocytes.