The only FDA-approved topical treatment for wrinkles is tretinoin, known commercially as Retin A. Ashinoff says this prescription cream reduces fine lines and large wrinkles, and repairs sun damage. Retinol is a natural form of vitamin A found in many over-the-counter products. Moisturizers can't prevent wrinkles, but they trap water in the skin, temporarily masking tiny lines and creases. Don't smoke. Smoking causes narrowing of the blood vessels in the outermost layers of your skin. It also damages collagen and elastin ? fibers that give your skin its strength and elasticity.
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