How Recombinant Human Endostatin Can Help You Improve Your Health.

Cmishivani11 Oct, 2021Technology

The amino-terminal noncollagenous domain of type XVIII collagen is a Recombinant Human Endostatin fragment, which is 20 kDa in size. The protein inhibits the proliferation and angiogenesis of endothelial cells without being glycosylated. Metalloproteinases like MMP2 and MMP9, as well as cathepsins S, B, and L, generate and/or trim it. The majority of Endostatin's action appears to be concentrated in its N-terminal 27 amino acids. This area comprises three zinc-binding sites that are thought to be important for its antiendothelial and antitumor properties, as well as several cleavage sites that can alter its activity when employed. Mouse, rat, bovine, and horse Endostatin share 84.7% aa sequence identity with Recombinant Human Endostatin.