High-Exp� Immunotoxins Production

Jerrycret6814 Sep, 2023Science

Immunotoxin is a human-made protein that consists of a targeting portion linked to a toxin. When the protein binds to that cell, it is taken in through endocytosis, and the toxin kills the cell. The toxin is usually a cytotoxic protein derived from a bacterial or plant protein, such as Diphtheria toxin (DT), Cholera toxin (CT), Trichosanthin (TCS), Dianthin etc.. The antibody transports the toxin in the body and selectively targets it to tumor cells by binding to a cell-surface antigen. The toxin then enters the cell and incapacitates it by irreversibly blocking an essential metabolic process. As it has little harm to normal tissues, it is vividly called "the biological missiles".