Occupational therapy (OT) is essential for helping individuals with physical, cognitive, and developmental challenges regain independence and improve their daily living skills. While traditional OT methods have achieved great success, there remains a need for more personalized treatment plans to enhance outcomes. Genetic engineering offers an innovative solution by tailoring therapy interventions based on an individual’s unique genetic makeup. This approach can potentially improve the effectiveness and efficiency of occupational therapy, making rehabilitation more targeted and individualized.