G Protein-biased kratom-alkaloids as potential treatments

Kratom Lords11 Dec, 2022Health

Background and Purpose Mitragyna speciosa, more commonly known as kratom, is a plant that contains opioidergic alkaloids but is unregulated in most countries. Kratom is used in the self-medication and may be less dangerous than typical opioids because of the stronger preference of kratom alkaloids to induce receptor interaction with G proteins over ?-arrestin proteins. The study hypothesizes that kratom (alkaloids) can also reduce alcohol intake.