Diethyl ether is a potent anesthetic whose actions are accompanied by analgesic and muscle relaxant activity. It has a long induction period and is highly flammable and explosive. Diethyl ether is probably the most commonly employed solvent for the extraction of clomiphene [14,16], For instance, clomiphene was extracted from 3 mL of plasma in 1 mL borate buffer, pH 9, with an extraction efficiency of 70% at 30 ng/mL .
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