The dermocosmetics market operates under diverse international regulations shaped by regional safety, efficacy, and labeling standards. Manufacturers must comply with varying frameworks, including EU’s Cosmetic Regulation and FDA oversight in the U.S. Stringent requirements related to active ingredients, product claims, and clinical validation are common. Asia-Pacific nations, particularly Japan and South Korea, enforce additional guidelines rooted in pharmaceutical-grade scrutiny. Harmonization remains a challenge due to fragmented rules. Companies investing in regulatory expertise and transparent documentation can achieve smoother market entry. Global compliance strategies are becoming essential as demand for science-backed skincare accelerates across borders, reshaping how products are developed and approved.