CiPA Translational Assays

Chelseaclark121 Dec, 2022Other

Induced pluripotent stem cells (iPSC) offer the potential to assess the risk of drug-induced pro-arrhythmia using a human derived model. The potential advantage is that it is possible to have an assay in which cells express a full range of ion channels as expressed in human ventricular myocytes. This approach is unique as cells can be differentiated to express not only normal, but also many variant cardiac disease phenotypes (e.g., LQTs), catecholaminergic polymorphic ventricular tachycardia (CPVT), overlap syndrome of cardiac Na+ channelopathy and arrhythmogenic right ventricular cardiomyopathy (ARVC).