Carfilzomib: A proteasome inhibitor drug

Indianpharma28 Apr, 2022Health

The drug Carfilzomib is the active ingredient in medicine, and the inactive ingredients are sulfobutylether beta-cyclodextrin, citric acid, and sodium hydroxide. Carfilzomib is a tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds to the N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core particle within the 26S proteasome. The medicine Carfilzomib 60 mg is supplied as single-dose vials for intravenous infusion. Carfilzomib is a tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds to the N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core particle within the 26S proteasome.