Avian influenza commonly known as bird flu is one of the biggest threats that the world has come across. It is estimated that WHO has recorded more than 860 human avian influenza outbreaks with those of the H5N1 strain having a mortality rate of more than 50%. Further, the 2022-2023 waves forced the depopulation of millions of birds globally, affecting the poultry sector and increasing worries about spillover. As the threat of new diseases continues to unfold, the need to develop avian influenza vaccines cannot be over-emphasized. But the question remains: are these vaccines enough to protect us from the next outbreak?
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