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The Hcg Institute07 Nov, 2022Health

Testicular Atrophy is a medical condition in which the testicles, located in the scrotum, shrink in size and may be accompanied by loss of function. This happens most commonly with long-term testosterone replacement therapy. When this exogenous testosterone is introduced into the bloodstream and binds to androgen receptors throughout the body, high testosterone levels trick your brain that your testicles are at work. The brain then stops releasing gonadotropin-releasing hormone (GnRH) which stimulates the production of Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) because the brain assumes that the rise in testosterone levels is a sign that you now have enough testosterone. FSH and LH cause the testes; production of testosterone and sperm in the testicle. So while the body enjoys the benefits of high serum testosterone, the testicles begin to shrink because it stops secreting testosterone.