Antibody Humanization

Vivian Smith30 Jun, 2024Health

Humanized antibody mainly refers to the re-expressed mouse monoclonal antibody modified by gene cloning and DNA recombination technology. Most of its amino acid sequence is replaced by human sequence, which basically retains the affinity and specificity of the parent mouse monoclonal antibody, but reduces Because of its heterogeneity, it can be applied to the human body. Humanized antibody means that the constant region of the antibody (ie, CH and CL regions) or all of the antibody is encoded by human antibody genes. Humanized antibodies can greatly reduce the immune side effects caused by heterologous antibodies to the human body. Humanized antibodies include chimeric antibodies, modified antibodies and fully humanized antibodies.