alternative pathway C3 convertase

Cailynnjohnson08 Mar, 2024Health

All pathways converge at the level of the C3 molecule, where downstream events can be amplified by a mechanism of positive feedback supported by complement convertases, the classical/lectin pathway C3 convertase (C4b2a) or the alternative pathway C3 convertase (C3bBb). C3 convertases cleave C3 into C3a, a chemoattractant molecule, and C3b, which covalently binds to target surfaces and triggers phagocytosis.