The acute repetitive seizure is a condition that occurs in patients with drug-refractory epilepsy. It is also known as cluster seizure, seizure flurry, breakthrough seizure, seizure cluster, serial seizure, or prolonged seizure. The acute repetitive seizure is characterized by the occurrence of seizures within short intervals, which could be within hours or even a few minutes. The frequency of occurrence of these seizures depends upon the type of epilepsy such as mesial temporal lobe epilepsy and the patient characteristics. Three catamenial seizures occur within two premenstrual days in women with mesial temporal lobe epilepsy. Rectal gels and nasal sprays are used for the management of acute repetitive seizures.