Adenocorticotropic hormone (ACTH) is produced and secreted by anterior pituitary gland. It is also called corticotropin, serum ACTH, etc. The hormone?s function is to regulate the levels of steroid hormone cortisol which is regulated by adrenal gland. ACTH is associated with diseases such as pituitary tumors and adrenal malfunctions. Deficiency of ACTH arises due to the absence or decreased production of adrenocorticotropic hormone, which leads to adrenal insufficiency. This results into weight loss, weakness, anorexia, nausea, etc. ACTH deficiency can either be acquired or congenital. The deficiency can be caused due to improper functioning of the pituitary gland. However, the exact cause of the diseases is unknown.